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Cortical spreading depression (CSD), characterized by a strong wave of neuronal depolarization accompanied by glial and vascular activation, is widely believed to underlie the aura phase of migraines (24)

References: (1) Vesely BA, Alli AA, Song SJ, Gower WR Jr, Sanchez-Ramos J, Vesely DL

Cell Stem Cell, 2019 doi:10.1016/j.stem.2019.08.013

Substance use was reported by 26.1% of the students, with a higher frequency in men (15.3%) than in women (10.8%

18 Endothelial dysfunction is a characteristic feature of patients with atherosclerosis and more recent studies indicate that it may predict long-term atherosclerotic disease progression as well as cardiovascular event rate